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. 2013 Sep 12;12(12):3744–3758. doi: 10.1074/mcp.M113.027441

Table I. Functional categorization of proteins differentially expressed in liver mitochondria of HFD vs. ND mice. +, fold changes (HFD/ND) of 1.5–2; ++, fold changes (HFD/ND) of 2–3; +++, fold changes (HFD/ND) > 3; −, down-regulated in HFD.

Gene symbol IPI number Protein name Changes p values
Fatty acid metabolism
    Aldh7a1 IPI00230084 Aldehyde dehydrogenase family 7, member A1 ++ 0.01
    Aldh1b1 IPI00113073 Aldehyde dehydrogenase X +++ 0.03
    Cpt1a IPI00330094 Cpt1a Carnitine O-palmitoyltransferase I, liver isoform ++ 0.04
    Hadh IPI00121105 Hydroxyacyl-coenzyme A dehydrogenase +++ 0.04
    Cpt2 IPI00131424 Carnitine O-palmitoyltransferase 2 +++ 0.06
    Hadha IPI00223092 Hydroxyacyl-Coenzyme A dehydrogenase, alpha subunit +++ 0.07
    Dci IPI00331692 Dci Dodecenoyl-Coenzyme A delta isomerase +++ 0.08
    Ehhadh IPI00554834 Ehhadh Peroxisomal bifunctional enzyme + 0.09
    Acadvl IPI00119203 Very-long-chain specific acyl-CoA dehydrogenase ++ 0.09
    Acaa2 IPI00653158 Acetyl-Coenzyme A acyltransferase 2 ++ 0.09
    Aldh2 IPI00111218 Aldehyde dehydrogenase +++ 0.10
    Hadhb IPI00115607 Trifunctional enzyme subunit beta +++ 0.17
    Acsl6 IPI00625955 Acsl6 Long-chain-fatty-acid–CoA ligase 6 +++ 0.18
    Acadm IPI00134961 Medium-chain specific acyl-CoA dehydrogenase +++ 0.20
Branched chain amino acid degradation
    Aldh7a1 IPI00230084 Aldehyde dehydrogenase family 7, member A1 ++ 0.01
    Auh IPI00124900 Isoform 1 of Methylglutaconyl-CoA hydratase ++ 0.01
    Ivd IPI00471246 Isovaleryl-CoA dehydrogenase + 0.02
    Aldh1b1 IPI00113073 Aldehyde dehydrogenase X +++ 0.03
    Hmgcs2 IPI00420718 Hydroxymethylglutaryl-CoA synthase +++ 0.03
    Hadh IPI00121105 Hydroxyacyl-coenzyme A dehydrogenase +++ 0.04
    Hadha IPI00223092 Hydroxyacyl-Coenzyme A dehydrogenase alpha subunit +++ 0.07
    Ehhadh IPI00554834 Peroxisomal bifunctional enzyme + 0.09
    Acaa2 IPI00653158 Acetyl-Coenzyme A acyltransferase 2 ++ 0.09
    Aldh2 IPI00111218 Aldehyde dehydrogenase +++ 0.10
    Pcca IPI00330523 Propionyl-CoA carboxylase alpha chain ++ 0.11
    Aldh6a1 IPI00461964 Aldehyde dehydrogenase family 6, subfamily A1 ++ 0.12
    Hadhb IPI00115607 Trifunctional enzyme subunit beta +++ 0.17
    Acadm IPI00134961 Medium-chain specific acyl-CoA dehydrogenase +++ 0.20
Pyruvate metabolism
    Aldh7a1 IPI00230084 Aldehyde dehydrogenase family 7, member A1 ++ 0.01
    Aldh1b1 IPI00113073 Aldehyde dehydrogenase X +++ 0.03
    Grhpr IPI00130530 Glyoxylate reductase/hydroxypyruvate reductase ++ 0.04
    Dlat IPI00153660 Dihydrolipoyllysine-residue acetyltransferase +++ 0.04
    Pdha1 IPI00337893 Pyruvate dehydrogenase E1 component alpha subunit, somatic form +++ 0.05
    Mdh2 IPI00323592 Malate dehydrogenase, mitochondrial precursor ++ 0.06
    Pdhb IPI00132042 Pyruvate dehydrogenase E1 component subunit beta ++ 0.06
    Pcx IPI00114710 Pyruvate carboxylase +++ 0.09
    Aldh2 IPI00111218 Aldehyde dehydrogenase +++ 0.10
TCA cycle
    Dlst IPI00134809 Isoform 1 of Dihydrolipoyllysine-residue succinyltransferase +++ 0.01
    Dlat IPI00153660 Dihydrolipoyllysine-residue acetyltransferase component +++ 0.04
    Pdha1 IPI00337893 Pyruvate dehydrogenase E1 component alpha subunit, somatic form +++ 0.05
    Mdh2 IPI00323592 Malate dehydrogenase ++ 0.06
    Pdhb IPI00132042 Pyruvate dehydrogenase E1 component subunit beta ++ 0.06
    Suclg1 IPI00406442 Succinyl-CoA ligase [GDP-forming] subunit alpha ++ 0.07
    Sdhb IPI00338536 Succinate dehydrogenase [ubiquinone] iron-sulfur subunit ++ 0.07
    Idh3a IPI00459725 Isoform 1 of Isocitrate dehydrogenase [NAD] subunit alpha + 0.09
    Pcx IPI00114710 Pyruvate carboxylase +++ 0.09
    Aco2 IPI00116074 Aco2 Aconitate hydratase, mitochondrial precursor +++ 0.10
    Suclg2 IPI00459487 Isoform 1 of Succinyl-CoA ligase [GDP-forming] beta-chain ++ 0.13
Component of 2-oxoglutarate dehydrogenase complex
Oxidative phosphorylation
    Cox6b1 IPI00225390 Cytochrome c oxidase subunit VIb isoform 1 ++ 0.00
    Atp5j IPI00125460 ATP synthase-coupling factor 6 ++ 0.00
    Uqcrc2 IPI00119138 Ubiquinol-cytochrome-c reductase complex core protein 2 ++ 0.01
    Cox7a2 IPI00114377 Cytochrome c oxidase polypeptide VIIa-liver/heart ++ 0.01
    Ndufs8 IPI00170093 NADH dehydrogenase [ubiquinone] iron-sulfur protein 8 ++ 0.01
    Ndufv2 IPI00169925 Isoform 1 of NADH dehydrogenase [ubiquinone] flavoprotein 2 ++ 0.02
    Ndufb7 IPI00133215 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 ++ 0.03
    Cox4i1 IPI00117978 Cytochrome c oxidase subunit 4 isoform 1 + 0.03
    Uqcrb IPI00132347 Ubiquinol-cytochrome-c reductase binding protein homolog +++ 0.04
    Atp5b IPI00468481 ATP synthase subunit beta ++ 0.04
    Atp5o IPI00118986 ATP synthase O subunit ++ 0.06
    Cyc1 IPI00845772 Isoform 2 of Cytochrome c1 heme protein ++ 0.06
    Sdhb IPI00338536 Succinate dehydrogenase [ubiquinone] iron-sulfur subunit ++ 0.07
    Ndufs1 IPI00308882 NADH-ubiquinone oxidoreductase 75 kDa subunit ++ 0.09
    Ndufs3 IPI00121309 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3 ++ 0.09
    Ndufb6 IPI00648743 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 6 ++ 0.11
    Atp5a1 IPI00130280 ATP synthase subunit alpha ++ 0.12
    Cox5a IPI00776087 Cytochrome c oxidase, subunit Va ++ 0.15
    Ndufs7 IPI00120232 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7 +++ 0.29
Protein QP-C
Retinol metabolism
    Cyp3a11 IPI00134504 Cytochrome P450 3A11 – 0.00
    Cyp2c29 IPI00134503 Cytochrome P450 2C29 – 0.02
    Cyp2c54 IPI00409800 Cytochrome P450 2C54 – 0.02
    Cyp4a12b IPI00828590 Cytochrome P450, family 4, subfamily a, polypeptide 12 – 0.03
    Cyp2c70 IPI00269265 Cytochrome P450 2C70 – 0.04
    Cyp1a2 IPI00128287 Cytochrome P450 1A2 – 0.05
    Cyp2a5 IPI00751041 Similar to cytochrome P450, family 2, subfamily a, polypeptide 5 – 0.05
    Retsat IPI00471380 All-trans-retinol 13,14-reductase precursor – 0.09
    Ugt2b1 IPI00153143 UDP glucuronosyltransferase 2 family, polypeptide B1 – 0.17