Abstract
Human taste perception was remarkably unimpaired in eight individuals with severe, chronic failure of all major and minor salivary gland function. Subjective reports of taste experience and objective measures of suprathreshold sensitivity were within normal limits for the overwhelming majority of these individuals. Impairments of threshold sensitivity for at least one quality was common, but normal thresholds for all four qualities were observed in one individual. These data demonstrated that the functional integrity of the taste system is not dependent upon the presence of normal saliva in the mouth. Thus, the suggestion that a salivary factor is responsible for the maintenance of taste receptor end organs can be rejected and attention directed toward other mechanisms, not dependent on saliva, that might account for the unusual resistance of these cells to environmental insult.
Full text
PDFSelected References
These references are in PubMed. This may not be the complete list of references from this article.
- Baum B. J. Characteristics of participants in the oral physiology component of the Baltimore longitudinal study of aging. Community Dent Oral Epidemiol. 1981 Jun;9(3):128–134. doi: 10.1111/j.1600-0528.1981.tb01043.x. [DOI] [PubMed] [Google Scholar]
- Chisholm D. M., Mason D. K. Labial salivary gland biopsy in Sjögren's disease. J Clin Pathol. 1968 Sep;21(5):656–660. doi: 10.1136/jcp.21.5.656. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Cowart B. J. Development of taste perception in humans: sensitivity and preference throughout the life span. Psychol Bull. 1981 Jul;90(1):43–73. [PubMed] [Google Scholar]
- Fox P. C. Simplified biopsy technique for labial minor salivary glands. Plast Reconstr Surg. 1985 Apr;75(4):592–593. doi: 10.1097/00006534-198504000-00029. [DOI] [PubMed] [Google Scholar]
- Fox P. C., van der Ven P. F., Sonies B. C., Weiffenbach J. M., Baum B. J. Xerostomia: evaluation of a symptom with increasing significance. J Am Dent Assoc. 1985 Apr;110(4):519–525. doi: 10.14219/jada.archive.1985.0384. [DOI] [PubMed] [Google Scholar]
- Greenspan J. S., Daniels T. E., Talal N., Sylvester R. A. The histopathology of Sjögren's syndrome in labial salivary gland biopsies. Oral Surg Oral Med Oral Pathol. 1974 Feb;37(2):217–229. doi: 10.1016/0030-4220(74)90417-4. [DOI] [PubMed] [Google Scholar]
- Grove A. S., Jr, Di Chiro G. Salivary gland scanning with technetium 99m pertechnetate. Am J Roentgenol Radium Ther Nucl Med. 1968 Jan;102(1):109–116. doi: 10.2214/ajr.102.1.109. [DOI] [PubMed] [Google Scholar]
- Henkin R. I., Lippoldt R. E., Bilstad J., Edelhoch H. A zinc protein isolated from human parotid saliva. Proc Natl Acad Sci U S A. 1975 Feb;72(2):488–492. doi: 10.1073/pnas.72.2.488. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Katz W. A., Ehrlich G. E., Gupta V. P., Shapiro B. Salivary gland dysfunction in systemic lupus erythematosus and rheumatoid arthritis. Diagnostic importance. Arch Intern Med. 1980 Jul;140(7):949–951. [PubMed] [Google Scholar]
- Mandel I. D., Katz R., Zengo A., Kutscher A. H., Greenberg R. A., Katz S., Scharf R., Pintoff A. The effect of pharmacologic agents on salivary secretion and composition in man. I. Pilocarpine, atropine and anticholinesterases. J Oral Ther Pharmacol. 1967 Nov;4(3):192–199. [PubMed] [Google Scholar]
- Shatzman A. R., Henkin R. I. Metal-binding characteristics of the parotid salivary protein gustin. Biochim Biophys Acta. 1980 May 29;623(1):107–118. doi: 10.1016/0005-2795(80)90013-6. [DOI] [PubMed] [Google Scholar]
- WETHERILL G. B., LEVITT H. SEQUENTIAL ESTIMATION OF POINTS ON A PSYCHOMETRIC FUNCTION. Br J Math Stat Psychol. 1965 May;18:1–10. doi: 10.1111/j.2044-8317.1965.tb00689.x. [DOI] [PubMed] [Google Scholar]
- Weiffenbach J. M., Baum B. J., Burghauser R. Taste thresholds: quality specific variation with human aging. J Gerontol. 1982 May;37(3):372–377. doi: 10.1093/geronj/37.3.372. [DOI] [PubMed] [Google Scholar]
- Weiffenbach J. M., Cowart B. J., Baum B. J. Taste intensity perception in aging. J Gerontol. 1986 Jul;41(4):460–468. doi: 10.1093/geronj/41.4.460. [DOI] [PubMed] [Google Scholar]
- van Bijsterveld O. P. Diagnostic tests in the Sicca syndrome. Arch Ophthalmol. 1969 Jul;82(1):10–14. doi: 10.1001/archopht.1969.00990020012003. [DOI] [PubMed] [Google Scholar]