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. 1986 Sep;83(17):6430–6434. doi: 10.1073/pnas.83.17.6430

Cyclosporin A prevents induction of the interleukin 2 receptor gene in cultured murine thymocytes.

J F Gauchat, E W Khandjian, R Weil
PMCID: PMC386517  PMID: 2428033

Abstract

Blast formation and mitotic activation of G0-arrested mouse thymocytes were triggered by the addition of concanavalin A plus interleukin 2 (IL-2) to the culture medium. When added alone, Con A induces within 6 hr a complex reprogramming ("priming") that comprises the activation of the IL-2 receptor gene. The primed thymocytes are competent to interact with IL-2 and to respond to its growth-promoting effect, which corresponds to blast formation and mitotic activation. Cyclosporin A, an immunosuppressive cyclic peptide of fungal origin, prevents in T lymphocytes the activation of a set(s) of genes encoding lymphokines and the IL-2 receptor but does not affect their expression once they have been activated. The biomedical implications of these observations are discussed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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