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. 1986 Sep;83(18):6883–6886. doi: 10.1073/pnas.83.18.6883

Identification of a paternal developmental effect on the cytoplasm of one-cell-stage mouse embryos.

J P Renard, C Babinet
PMCID: PMC386614  PMID: 3462735

Abstract

Matings of female DDK mice with males of the BALB/c strain are sterile, whereas reciprocal crosses are normally fertile. We used nuclear transplantation between the hybrid eggs of these two strains to investigate the basis of this effect. We demonstrate that the observed sterility results from early embryonic mortality, that the mortality is due to a modification of the egg cytoplasm, and that the modification is mediated by the male pronucleus. Once established, this modification may affect female pronuclei of unrelated genotype such as C57BL/6. These results support the notion that a product derived from the male genome acts at the pronuclear stage and can affect later stages of embryonic development.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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