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. 1986 Sep;83(18):7003–7007. doi: 10.1073/pnas.83.18.7003

IgD-binding factors from mouse T lymphocytes.

M Adachi, K Ishizaka
PMCID: PMC386640  PMID: 2944119

Abstract

Incubation of normal mouse splenic lymphocytes with dimeric mouse IgD results in the formation of T-cell factors that selectively inhibit rosette formation of Fc delta receptor-positive lymphocytes with IgD-coated erythrocytes. The rosette-inhibiting factors bound to IgD-Sepharose and were recovered by elution at acid pH. The results indicate that the rosette-inhibiting factors are IgD-binding factors. Neither IgE-binding factors nor IgG-binding factors inhibited IgD rosettes. The IgD-binding factors induced by IgD consist of two species of molecular weight 78,000 and 37,000, respectively. The source of IgD-binding factors is Lyt-1+ T cells bearing Fc delta receptors. It appears that the binding of IgD to the receptors on the T cells induces the formation of IgD-binding factors.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Coico R. F., Xue B., Wallace D., Pernis B., Siskind G. W., Thorbecke G. J. T cells with receptors for IgD. Nature. 1985 Aug 22;316(6030):744–746. doi: 10.1038/316744a0. [DOI] [PubMed] [Google Scholar]
  2. Coico R. F., Xue B., Wallace D., Siskind G. W., Thorbecke G. J. Physiology of IgD. VI. Transfer of the immunoaugmenting effect of IgD with T delta-containing helper cell populations. J Exp Med. 1985 Dec 1;162(6):1852–1861. doi: 10.1084/jem.162.6.1852. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Finkelman F. D., Kessler S. W., Mushinski J. F., Potter M. IgD-secreting murine plasmacytomas: identification and partial characterization of two IgD myeloma proteins. J Immunol. 1981 Feb;126(2):680–687. [PubMed] [Google Scholar]
  4. Fridman W. H., Golstein P. Immunoglobulin-binding factor present on and produced by thymus-processed lymphocytes (T cells). Cell Immunol. 1974 Mar 30;11(1-3):442–455. doi: 10.1016/0008-8749(74)90042-2. [DOI] [PubMed] [Google Scholar]
  5. Fridman W. H., Nelson R. A., Jr, Liabeuf A. Production of an immunoglobulin-binding factor (IBF) by antigen-stimulated lymph node lymphocytes. J Immunol. 1974 Sep;113(3):1008–1016. [PubMed] [Google Scholar]
  6. Fridman W. H., Rabourdin-Combe C., Neauport-Sautes C., Gisler R. H. Characterization and function of T cell Fc gamma receptor. Immunol Rev. 1981;56:51–88. doi: 10.1111/j.1600-065x.1981.tb01047.x. [DOI] [PubMed] [Google Scholar]
  7. Gonzalez-Molina A., Spiegelberg H. L. A subpopulation of normal human peripheral B lymphcytes that bind IgE. J Clin Invest. 1977 Apr;59(4):616–624. doi: 10.1172/JCI108679. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Hoover R. G., Dieckgraefe B. K., Lake J., Kemp J. D., Lynch R. G. Lymphocyte surface membrane immunoglobulin in myeloma. III. IgA plasmacytomas induce large numbers of circulating, adult-thymectomy-sensitive, theta +, Lyt-1-2+ lymphocytes with IgA-Fc receptors. J Immunol. 1982 Dec;129(6):2329–2331. [PubMed] [Google Scholar]
  9. Huff T. F., Ishizaka K. Formation of IgE-binding factors by human T-cell hybridomas. Proc Natl Acad Sci U S A. 1984 Mar;81(5):1514–1518. doi: 10.1073/pnas.81.5.1514. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Huff T. F., Uede T., Ishizaka K. Formation of rat IgE-binding factors by rat-mouse T cell hybridomas. J Immunol. 1982 Aug;129(2):509–514. [PubMed] [Google Scholar]
  11. Huff T. F., Yodoi J., Uede T., Ishizaka K. Presence of an antigenic determinant common to rat IgE-potentiating factor, IgE-suppressive factor, and Fc epsilon receptors on T and B lymphocytes. J Immunol. 1984 Jan;132(1):406–412. [PubMed] [Google Scholar]
  12. Ishizaka K. Regulation of IgE synthesis. Annu Rev Immunol. 1984;2:159–182. doi: 10.1146/annurev.iy.02.040184.001111. [DOI] [PubMed] [Google Scholar]
  13. Jardieu P., Uede T., Ishizaka K. Presence of an antigen-specific T cell subset that forms IgE-suppressive factor and IgG-suppressive factor on antigenic stimulation. J Immunol. 1985 Aug;135(2):922–929. [PubMed] [Google Scholar]
  14. Liu F. T., Bohn J. W., Ferry E. L., Yamamoto H., Molinaro C. A., Sherman L. A., Klinman N. R., Katz D. H. Monoclonal dinitrophenyl-specific murine IgE antibody: preparation, isolation, and characterization. J Immunol. 1980 Jun;124(6):2728–2737. [PubMed] [Google Scholar]
  15. Löwy I., Brezin C., Neauport-Sautes C., Theze J., Fridman W. H. Isotype regulation of antibody production: T-cell hybrids can be selectively induced to produce IgG1 and IgG2 subclass-specific suppressive immunoglobulin-binding factors. Proc Natl Acad Sci U S A. 1983 Apr;80(8):2323–2327. doi: 10.1073/pnas.80.8.2323. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Mage M. G., McHugh L. L., Rothstein T. L. Mouse lymphocytes with and without surface immunoglobulin: preparative scale separation in polystyrene tissue culture dishes coated with specifically purified anti-immunoglobulin. J Immunol Methods. 1977;15(1):47–56. doi: 10.1016/0022-1759(77)90016-3. [DOI] [PubMed] [Google Scholar]
  17. Marcelletti J. F., Katz D. H. FcR epsilon+ lymphocytes and regulation of the IgE antibody system. I. A new class of molecules, termed IgE-induced regulants (EIR), which modulate FcR epsilon expression by lymphocytes. J Immunol. 1984 Dec;133(6):2821–2828. [PubMed] [Google Scholar]
  18. Marcelletti J. F., Katz D. H. FcR epsilon+ lymphocytes and regulation of the IgE antibody system. IV. Delineation of target cells and mechanisms of action of SFA and EFA in inhibiting in vitro induction of FcR epsilon expression. J Immunol. 1984 Dec;133(6):2845–2851. [PubMed] [Google Scholar]
  19. Okudaira H., Ishizaka K. Reaginic antibody formation in the mouse. IV. Adoptive anti-hapten IgE antibody response in irradiated recipients of hapten-primed cells and carrier-specific cells. J Immunol. 1974 Aug;113(2):563–573. [PubMed] [Google Scholar]
  20. Suemura M., Ishizaka A., Kobatake S., Sugimura K., Maeda K., Nakanishi K., Kishimoto S., Yamamura Y., Kishimoto T. Inhibition of IgE production in B hybridomas by IgE class-specific suppressor factor from T hybridomas. J Immunol. 1983 Mar;130(3):1056–1060. [PubMed] [Google Scholar]
  21. Uede T., Huff T. F., Ishizaka K. Formation of IgE-binding factors by rat T lymphocytes. V. Effect of adjuvant for the priming immunization on the nature of IgE binding factors formed by antigenic stimulation. J Immunol. 1982 Oct;129(4):1384–1390. [PubMed] [Google Scholar]
  22. Uede T., Huff T. F., Ishizaka K. Suppression of IgE synthesis in mouse plasma cells and B cells by rat IgE-suppressive factor. J Immunol. 1984 Aug;133(2):803–808. [PubMed] [Google Scholar]
  23. Xue B., Coico R., Wallace D., Siskind G. W., Pernis B., Thorbecke G. J. Physiology of IgD. IV. Enhancement of antibody production in mice bearing IgD-secreting plasmacytomas. J Exp Med. 1984 Jan 1;159(1):103–113. doi: 10.1084/jem.159.1.103. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Yodoi J., Adachi M., Masuda T. Induction of FcR alpha on murine lymphocytes by IgA in vitro. J Immunol. 1982 Feb;128(2):888–894. [PubMed] [Google Scholar]
  25. Yodoi J., Adachi M., Teshigawara K., Miyamainaba M., Masuda T., Fridman W. H. T cell hybridomas coexpressing Fc receptors (FcR) for different isotypes. II. IgA-induced formation of suppressive IgA binding factor(s) by a murine T hybridoma bearing Fc gamma R and Fc alpha R. J Immunol. 1983 Jul;131(1):303–310. [PubMed] [Google Scholar]
  26. Yodoi J., Hirashima M., Ishizaka K. Regulatory role of IgE-binding factors from rat T lymphocytes. II. Glycoprotein nature and source of IgE-potentiating factor. J Immunol. 1980 Oct;125(4):1436–1441. [PubMed] [Google Scholar]
  27. Yodoi J., Ishizaka K. Lymphocytes bearing Fc receptors for IgE. I. Presence of human and rat T lymphocytes with Fc epsilon receptors. J Immunol. 1979 Jun;122(6):2577–2583. [PubMed] [Google Scholar]
  28. Yodoi J., Ishizaka K. Lymphocytes bearing Fc receptors for IgE. IV. Formation of IgE-binding factor by rat T lymphocytes. J Immunol. 1980 Mar;124(3):1322–1329. [PubMed] [Google Scholar]
  29. Yodoi J., Ishizaka K. Lymphocytes bearing receptors for IgE. III. Transition of Fc gamma R(+) cells to Fc epsilon R(4) cells by IgE. J Immunol. 1979 Nov;123(5):2004–2010. [PubMed] [Google Scholar]

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