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. 1986 Oct;83(19):7307–7310. doi: 10.1073/pnas.83.19.7307

Regulation of melanoma by the embryonic skin.

M Gerschenson, K Graves, S D Carson, R S Wells, G B Pierce
PMCID: PMC386705  PMID: 3463969

Abstract

This report focuses on the regulation of murine melanoma by the embryonic skin. A surgical technique was developed to allow injection of B16 melanoma cells into the embryo in utero. A significant decrease in incidence of tumors was noted, which correlated with the time of arrival of normally migrating premelanocytes into the skin. Media were conditioned from skin explanted at the time premelanocytes arrive in it; these media inhibited the growth of melanoma cells in vitro. Under optimal conditions the growth of melanoma cells ceased; the cells had altered morphology and failed to proliferate when placed in fresh growth media.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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