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. 1986 Oct;83(19):7325–7329. doi: 10.1073/pnas.83.19.7325

Long-term expression of isomyosins and myoendocrine functions in ectopic grafts of atrial tissue.

H Jockusch, E M Füchtbauer, A Füchtbauer, J J Leger, J Leger, C A Maldonado, W G Forssmann
PMCID: PMC386709  PMID: 3463971

Abstract

Tissue fragments of newborn rat atria were transplanted under the dorsal skin or into the bed of the anterior tibial muscle of nude mice. After 5-11 weeks, the grafts, which had reorganized into beating atrium-like structures, were analyzed and compared to ventricular tissue transplanted the same way. As revealed by monoclonal antibodies against alpha- and beta-type myosin heavy chains, atrial grafts retained a typical pattern of myosin expression distinct from that of ventricular grafts. The majority of ectopic atrial myocytes contained specific atrial granules in which cardiodilatin-immunoreactive material has been localized. Specific granules and cardiodilatin immunoreactivity were not found in myocytes of ventricular grafts. We conclude that the long-term maintenance of isomyosin expression and of the myoendocrine function of atrial tissue is largely independent of the anatomical environment.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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