Skip to main content
NCBI home page
Proceedings of the National Academy of Sciences of the United States of America logoLink to Proceedings of the National Academy of Sciences of the United States of America
. 1986 Oct;83(20):7947–7950. doi: 10.1073/pnas.83.20.7947

Oral immunization and protection of raccoons (Procyon lotor) with a vaccinia-rabies glycoprotein recombinant virus vaccine.

C E Rupprecht, T J Wiktor, D H Johnston, A N Hamir, B Dietzschold, W H Wunner, L T Glickman, H Koprowski
PMCID: PMC386841  PMID: 3464010

Abstract

Animal rabies control has been frustrated by the existence of multiple wildlife reservoirs and the lack of efficacious oral vaccines. In this investigation, raccoons fed a vaccinia-rabies glycoprotein recombinant virus in a sponge bait developed rabies virus-neutralizing antibody (0.6-54.0 units) and resisted street rabies virus infection 28 and 205 days after feeding. Additional raccoons immunized by oral infusion with attenuated antigenic variants of rabies virus strains CVS-11 and ERA failed to develop rabies virus-neutralizing antibody. This work demonstrates the feasibility of a recombinant virus vaccine containing the rabies glycoprotein gene for immunization of raccoons, and possibly other wildlife, to obtain long-term protection against rabies.

Full text

PDF
7947

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Abelseth M. K. An Attenuated Rabies Vaccine for Domestic Animals Produced in Tissue Culture. Can Vet J. 1964 Nov;5(11):279–286. [PMC free article] [PubMed] [Google Scholar]
  2. Baer G. M., Abelseth M. K., Debbie J. G. Oral vaccination of foxes against rabies. Am J Epidemiol. 1971 Jun;93(6):487–490. doi: 10.1093/oxfordjournals.aje.a121283. [DOI] [PubMed] [Google Scholar]
  3. Celis E., Wiktor T. J., Dietzschold B., Koprowski H. Amplification of rabies virus-induced stimulation of human T-cell lines and clones by antigen-specific antibodies. J Virol. 1985 Nov;56(2):426–433. doi: 10.1128/jvi.56.2.426-433.1985. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Debbie J. G., Abelseth M. K., Baer G. M. The use of commercially available vaccines for the oral vaccination of foxes against rabies. Am J Epidemiol. 1972 Sep;96(3):231–235. doi: 10.1093/oxfordjournals.aje.a121453. [DOI] [PubMed] [Google Scholar]
  5. Dietzschold B., Wunner W. H., Wiktor T. J., Lopes A. D., Lafon M., Smith C. L., Koprowski H. Characterization of an antigenic determinant of the glycoprotein that correlates with pathogenicity of rabies virus. Proc Natl Acad Sci U S A. 1983 Jan;80(1):70–74. doi: 10.1073/pnas.80.1.70. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. KISSLING R. E. Growth of rabies virus in non-nervous tissue culture. Proc Soc Exp Biol Med. 1958 Jun;98(2):223–225. doi: 10.3181/00379727-98-23997. [DOI] [PubMed] [Google Scholar]
  7. Kieny M. P., Lathe R., Drillien R., Spehner D., Skory S., Schmitt D., Wiktor T., Koprowski H., Lecocq J. P. Expression of rabies virus glycoprotein from a recombinant vaccinia virus. Nature. 1984 Nov 8;312(5990):163–166. doi: 10.1038/312163a0. [DOI] [PubMed] [Google Scholar]
  8. Reagan K. J., Wunner W. H., Wiktor T. J., Koprowski H. Anti-idiotypic antibodies induce neutralizing antibodies to rabies virus glycoprotein. J Virol. 1983 Dec;48(3):660–666. doi: 10.1128/jvi.48.3.660-666.1983. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Smith J. S., McCelland C. L., Reid F. L., Baer G. M. Dual role of the immune response in street rabiesvirus infection of mice. Infect Immun. 1982 Jan;35(1):213–221. doi: 10.1128/iai.35.1.213-221.1982. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Smith J. S., Yager P. A., Baer G. M. A rapid tissue culture test for determining rabies neutralizing antibody. Monogr Ser World Health Organ. 1973;(23):354–357. [PubMed] [Google Scholar]
  11. Steck F., Wandeler A. The epidemiology of fox rabies in Europe. Epidemiol Rev. 1980;2:71–96. doi: 10.1093/oxfordjournals.epirev.a036227. [DOI] [PubMed] [Google Scholar]
  12. Wiktor T. J., Koprowski H. Antigenic variants of rabies virus. J Exp Med. 1980 Jul 1;152(1):99–112. doi: 10.1084/jem.152.1.99. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Wiktor T. J. Laboratoty techniques in rabies: tissue culture methods. Monogr Ser World Health Organ. 1973;(23):101–123. [PubMed] [Google Scholar]
  14. Wiktor T. J., Macfarlan R. I., Reagan K. J., Dietzschold B., Curtis P. J., Wunner W. H., Kieny M. P., Lathe R., Lecocq J. P., Mackett M. Protection from rabies by a vaccinia virus recombinant containing the rabies virus glycoprotein gene. Proc Natl Acad Sci U S A. 1984 Nov;81(22):7194–7198. doi: 10.1073/pnas.81.22.7194. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Proceedings of the National Academy of Sciences of the United States of America are provided here courtesy of National Academy of Sciences

RESOURCES