Table 1. Distribution of Recurrence Score categories by patient/tumour characteristics.
| Parameter | Recurrence Score | ||
|---|---|---|---|
| Low | Intermediate | High | |
| Age (N = 751)a | |||
| 18–44 years (n = 138) | 62 (44.9%) | 58 (42.0%) | 18 (13.1%) |
| 45–64 years (n = 485) | 267 (55.1%) | 184 (37.9%) | 34 (7.0%) |
| ≥ 65 years (n = 128) | 78 (60.9%) | 43 (33.6%) | 7 (5.5%) |
| Histology subtype (N = 713)b | |||
| IDC not specified (n = 590) | 314 (53.2%) | 228 (38.6%) | 48 (8.1%) |
| IDC favourable (n = 21) | 12 (57.1%) | 7 (33.3%) | 2 (9.5%) |
| ILC/mixed (n = 102) | 67 (65.7%) | 33 (32.4%) | 2 (2.0%) |
| Grade/size combination (N = 605)c | |||
| Grade 2, ≤ 1 cm (n = 113) | 62 (54.9%) | 47 (41.6%) | 4 (3.5%) |
| Grade 3, ≤ 1 cm (n = 28) | 7 (25.0%) | 12 (42.9%) | 9 (32.1%) |
| Grade 1, > 1 cm (n = 101) | 60 (59.4%) | 38 (37.6%) | 3 (3.0%) |
| Grade 2, > 1 cm (n = 363) | 200 (55.1%) | 131 (36.1%) | 32 (8.8%) |
| Ki-67 levels (N = 389)d | |||
| ≤ 15% (n = 251) | 156 (62.2%) | 86 (34.3%) | 9 (3.6%) |
| > 15% (n = 138) | 55 (39.9%) | 59 (42.8%) | 24 (17.4%) |
All patients. P = 0.002; Mantel-Haenszel Chi-squared test for association between age and Recurrence Score groups.
MHS-eligible patients. P = 0.02 for overall differences between subtypes (Cochran-Mantel-Haenszel Row Mean Score test). Pairwise comparisons: P = 0.017 for IDC not specified v/s ILC/mixed (Cochran-Mantel-Haenszel Row Mean Score test using the Bonferroni correction). All other pairwise comparisons were nonsignificant.
MHS-eligible patients with grade/size information. P < 0.0001 for overall differences between grade/size combinations (Cochran-Mantel-Haenszel Row Mean Score test). Pairwise comparisons: P < 0.0005 for Grade 3 and ≤ 1 cm v/s all other grade/size combinations (Cochran-Mantel-Haenszel Row Mean Score test using the Bonferroni correction). All other pairwise comparisons were nonsignificant.
MHS-eligible patients with Ki-67 information. P < 0.0001 for overall differences between patients with Ki-67 ≤ 15% and > 15% (Cochran-Mantel-Haenszel Row Mean Score test).