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. 1986 Nov;83(22):8699–8702. doi: 10.1073/pnas.83.22.8699

Genes for the tumor necrosis factors alpha and beta are linked to the human major histocompatibility complex.

T Spies, C C Morton, S A Nedospasov, W Fiers, D Pious, J L Strominger
PMCID: PMC386998  PMID: 3464978

Abstract

The human major histocompatibility complex (MHC) includes the closely linked genes for the tumor necrosis factors alpha and beta. Their location is within the chromosomal segment between HLA-DR and HLA-A or centromeric of HLA-DP. This assignment is based on Southern blot analysis of a number of different MHC deletion mutants and is corroborated by chromosome in situ hybridization.

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