Figure 1.

Chronic, but not acute, treatment with PPF impairs cocaine reinstatement. Top, lever presses during self-administration and extinction (a) and reinstatement (b) for acute treatment groups. (b) A repeated measure two-way ANOVA revealed significant reinstatement, but no difference in reinstatement between treatment groups receiving acute saline, or PPF 10 or 25 mg/kg. Bottom, lever presses during self-administration and extinction (c) and reinstatement (d) for chronic treatment groups. In contrast to acute PPF, chronic administration of 10 mg/kg PPF significantly impaired cue- and cocaine-primed reinstatement compared with saline treatment. Self-administration and extinction profiles were not significantly different for animals receiving chronic saline or PPF prior to cocaine-primed reinstatement (data not shown). *p<0.05.