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. 1986 Dec;83(23):9174–9178. doi: 10.1073/pnas.83.23.9174

A synthetic peptide vaccine involving the product of the pre-S(2) region of hepatitis B virus DNA: protective efficacy in chimpanzees.

Y Itoh, E Takai, H Ohnuma, K Kitajima, F Tsuda, A Machida, S Mishiro, T Nakamura, Y Miyakawa, M Mayumi
PMCID: PMC387097  PMID: 3466181

Abstract

The S gene encoding the major surface polypeptide of hepatitis B virus is preceded by the region pre-S(2) with a capacity to code for 55 amino acid residues. In the product of region pre-S(2), the sequence of 19 amino acid residues (amino acids 14-32 from the N terminus) representing an area of high local hydrophilicity is shared by viral strains of subtypes adr, ayw, and ayr; residue 22, phenylalanine, is replaced by leucine in a strain of the other subtype, adw. A synthetic peptide vaccine involving these 19 amino acid residues, when given to two chimpanzees, raised antibodies that bound to viral particles and protected the animals from challenge with 10(6) chimpanzee infectious doses of hepatitis B virus.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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