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. Author manuscript; available in PMC: 2013 Dec 31.
Published in final edited form as: Shock. 2010 Mar;33(3):10.1097/SHK.0b013e3181b2f439. doi: 10.1097/SHK.0b013e3181b2f439

Figure 3. Severe burn injury is associated with activation of ER stress signaling pathways and phosphorylation of IRS-1 at its serine binding site.

Figure 3

Accumulation of phospho-PERK/PERK (A), phospho-IRE-1/IRE-1 (C), phospho-JNK/JNK (E) and phospho-IRS-1(Ser307)/IRS-1 (G) was determined in liver tissue isolated at 24, 72 and 192 h after burn or sham procedure. GAPDH served as control loading protein. Histograms depict intensities of the phosphorylated protein bands divided by the total form of the respective protein (B, D, F, H). Results shown represent three to five different animals per group, as indicated in the main text. Bars represent means; error bars correspond to S.E.M. Asterisks denote statistical significance: p < 0.05 for every comparison between groups.