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. Author manuscript; available in PMC: 2013 Dec 31.
Published in final edited form as: Shock. 2010 Mar;33(3):10.1097/SHK.0b013e3181b2f439. doi: 10.1097/SHK.0b013e3181b2f439

Figure 6. Molecular mechanisms underlying insulin resistance following thermal injury.

Figure 6

Severe burn is associated activation of ER-stress related signaling pathways, indicated by activation of PERK and IRE-1. Phosphorylation of IRE-1 causes activation of c-JNK. Activation of JNK may then lead to phosphorylation of IRS-1 at serine residues which may preclude its tyrosine phosphorylation by the insulin receptor tyrosine kinase, thus resulting in impaired PI3K/Akt signaling and insulin resistance with its associated consequences.