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. 1974 Jan;71(1):110–113. doi: 10.1073/pnas.71.1.110

Restoration of the Conversion of Desmosterol to Cholesterol in L-Cells after Hybridization with Human Fibroblasts

C M Croce 1, I Kieba 1, H Koprowski 1, M Molino 1, G H Rothblat 1
PMCID: PMC387944  PMID: 4359325

Abstract

Hybrids between different human cells (which synthesize cholesterol) and mouse cells (whose end-product of sterol synthesis is desmosterol) were analyzed for the ability to convert desmosterol to cholesterol. Conversion of [14C]desmosterol to cholesterol and incorporation of [14C]acetate into the end-product sterol were studied in the parental and hybrid cells. Concordant segregation of the conversion of desmosterol to cholesterol and the human chromosome F-20 was observed.

Keywords: interspecific hybrids, rat-mouse hybrids, G-banding

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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