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. 1974 Feb;71(2):298–301. doi: 10.1073/pnas.71.2.298

Absence of a Specific Ganglioside Galactosyltransferase in Mouse Cells Transformed by Murine Sarcoma Virus

Peter H Fishman *, Roscoe O Brady *, Roy M Bradley *, Stuart A Aaronson †, George J Todaro ‡
PMCID: PMC387990  PMID: 4360937

Abstract

The ganglioside composition of a nonproducer subclone (derived from BALB/c 3T3 mouseembryo cells) transformed by Kirsten murine sarcoma virus was drastically altered compared to the nontransformed parental clone. The transformed clone was unable to synthesize the mono- and disialogangliosides, GM1 and GD1a, due to the complete absence of a specific galactosyltransferase. The lack of this enzyme activity was established by sensitive radiochemical and enzymological techniques in vivo and in vitro.

Keywords: RNA tumor virus, transformation

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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