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. 1974 Feb;71(2):427–430. doi: 10.1073/pnas.71.2.427

A Comparison of Bovine Prothrombin, Factor IX (Christmas Factor), and Factor X (Stuart Factor)*

Kazuo Fujikawa 1, Michael H Coan 1, David L Enfield 1, Koiti Titani 1, Lowell H Ericsson 1, Earl W Davie 1
PMCID: PMC388019  PMID: 4205592

Abstract

A comparison has been made of the electrophoretic behavior, chemical composition, amino-terminal sequence, and immunological properties of bovine prothrombin, factor IX (Christmas factor), and factor X (Stuart factor). Some immunological crossreactivity was found between the antibody to prothrombin and factor X although prothrombin and factor X differ substantially in amino-acid and carbohydrate composition. Considerable amino-acid sequence homology was found in the amino-terminal portion of prothrombin, factor IX, and the light chain of factor X. These data provide further evidence to support the hypothesis that at least three of the vitamin K-dependent clotting factors have evolved from a common ancestral gene.

Keywords: blood coagulation, glycoprotein, homology, immunology

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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