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Proceedings of the National Academy of Sciences of the United States of America logoLink to Proceedings of the National Academy of Sciences of the United States of America
. 1974 Feb;71(2):573–577. doi: 10.1073/pnas.71.2.573

Immunostimulation with Bacterial Phospholipid Extracts

Robert M Fauve 1, Brigitte Hevin 1
PMCID: PMC388050  PMID: 4205595

Abstract

Injection of bacterial phospholipid extracts (EBP) into mice increased their resistance towards a Listeria monocytogenes infection. The blood clearance of virulent Salmonella typhimurium was enhanced and the degree of clearance correlated with the dose of extract injected. The multiplication of Listeria monocytogenes in spleen and liver of mice was inhibited and this inhibition was also correlated with the amount of extract injected. The absence of apparent toxicity in mice, of splenoand hepatomegaly, and of lymphoid hyperplasia, distinguish this immunostimulant from other known bacterial stimulants of host resistance to infection.

Keywords: macrophages, nonspecific immunity, Listeria monocytogenes, Salmonella typhimurium

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BIOZZI G., BENACERRAF B., GRUMBACH F., HALPERN B. N., LEVADITI J., RIST N. Etude de l'activité granulopexique du système réticulo-endothélial au cours de l'infection tuberculeuse expérimentale de la souris. Ann Inst Pasteur (Paris) 1954 Sep;87(3):291–300. [PubMed] [Google Scholar]
  2. BIOZZI G., BENACERRAF B., HALPERN B. N. The effect of Salm. typhi and its endotoxin on the phagocytic activity of the reticuloendothelial system in mice. Br J Exp Pathol. 1955 Jun;36(3):226–235. [PMC free article] [PubMed] [Google Scholar]
  3. DUBOS R. J., SCHAEDLER R. W. Reversible changes in the susceptibility of mice to bacterial infections. I. Changes brought about by injection of pertussis vaccine or of bacterial endotoxins. J Exp Med. 1956 Jul 1;104(1):53–65. doi: 10.1084/jem.104.1.53. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. FAUVE R. M., PIERCE-CHASE C. H., DUBOS R. CORYNEBACTERIAL PSEUDOTUBERCULOSIS IN MICE. II. ACTIVATION OF NATURAL AND EXPERIMENTAL LATENT INFECTIONS. J Exp Med. 1964 Aug 1;120:283–304. doi: 10.1084/jem.120.2.283. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. FOLCH J., LEES M., SLOANE STANLEY G. H. A simple method for the isolation and purification of total lipides from animal tissues. J Biol Chem. 1957 May;226(1):497–509. [PubMed] [Google Scholar]
  6. HALPERN B. N., PREVOT A. R., BIOZZI G., STIFFEL C., MOUTON D., MORARD J. C., BOUTHILLIER Y., DECREUSEFOND C. STIMULATION DE L'ACTIVIT'E PHAGOCYTAIRE DU SYST'EME R'ETICULOENDOTH'ELIAL PROVOQU'EE PAR CORYNEBACTERIUM PARVUM. J Reticuloendothel Soc. 1964 Jan;1:77–96. [PubMed] [Google Scholar]
  7. Mackaness G. B., Blanden R. V. Cellular immunity. Prog Allergy. 1967;11:89–140. [PubMed] [Google Scholar]
  8. PIERCE C. H., DUBOS R. J., SCHAEFER W. B. Multiplication and survival of tubercle bacilli in the organs of mice. J Exp Med. 1953 Feb 1;97(2):189–206. doi: 10.1084/jem.97.2.189. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. RIBI E., LARSON C. L., WICHT W., LIST R., GOODE G. RESISTANCE TO EXPERIMENTAL TUBERCULOSIS STIMULATED BY FRACTIONS FROM ATTENUATED TUBERCLE BACILLI. Proc Soc Exp Biol Med. 1965 Apr;118:926–933. doi: 10.3181/00379727-118-30009. [DOI] [PubMed] [Google Scholar]
  10. THORBECKE G. J., BENACERRAF B. The reticulo-endothelial system and immunological phenomena. Prog Allergy. 1962;6:559–598. [PubMed] [Google Scholar]
  11. WEISS D. W., DUBOS R. J. Antituberculous immunity induced in mice by vaccination with killed tubercle bacilli or with a soluble bacillary extract. J Exp Med. 1955 Mar 1;101(3):313–330. doi: 10.1084/jem.101.3.313. [DOI] [PMC free article] [PubMed] [Google Scholar]

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