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. 1974 Mar;71(3):694–698. doi: 10.1073/pnas.71.3.694

Intracellular Cyclic AMP Concentration Responds Specifically to Growth Regulation by Serum*

Jan Oey 1,†, Arthur Vogel 1, Robert Pollack 1,‡
PMCID: PMC388079  PMID: 4362627

Abstract

Intracellular concentrations of cyclic AMP increase when cells are deprived of serum. Studies with the mouse fibroblast line 3T3, an SV40-transformed subline of 3T3, and six different revertant lines derived from this clone show that a marked increase in cyclic AMP occurs only when the serum concentration is reduced below the minimum necessary for growth of a given line. Conversely, density-dependent inhibition of growth is not accompanied by an increase in cyclic AMP concentration in any line.

Keywords: transformation, reversion, mouse fibroblasts, serum requirement, density-dependent growth inhibition

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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