Skip to main content
. Author manuscript; available in PMC: 2014 Mar 19.
Published in final edited form as: Oncogene. 2012 Oct 29;32(38):10.1038/onc.2012.480. doi: 10.1038/onc.2012.480

Figure 5. Dual role for increased BAG-1 expression in promoting progression of colorectal tumorigenesis.

Figure 5

Increased expression of BAG-1 in the adenoma [12] (potentially due to de-regulation of C-MYC expression [36]) leads to suppression of TGF-β1 resulting in loss of growth inhibition and increased c-MYC activity. Increased BAG-1 expression also suppresses c-MYC induced apoptosis hence further promoting tumour cell survival. [Dotted line represents MYC-independent regulation of proliferation by TGF-β1.]