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. 1974 Mar;71(3):769–773. doi: 10.1073/pnas.71.3.769

Independent Regulation of the Nuclear RNA Polymerases I and II During the Yeast Cell Cycle

Jesus Sebastian 1, Isamu Takano 1, Harlyn O Halvorson 1
PMCID: PMC388095  PMID: 4595571

Abstract

The activities of the nuclear RNA polymerases I and II have been investigated in cells of Sacharomyces cerevisiae at G1, S, early G2, and late G2 stages of the cell cycle. The results show that the ratio of the activities of the two enzymes is different at these four stages, indicating that the two RNA polymerases are regulated independently during the cell cycle. The specific activity of the RNA polymerase I remains constant but that of RNA polymerase II increases sharply in cells at the beginning of the G2 phase. These results are compatible with a pattern of continuous synthesis of the RNA polymerase I and step-wise synthesis of the RNA polymerase II during the yeast cell cycle.

Keywords: Saccharomyces cerevisiae, cell separation, template specificity

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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