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Proceedings of the National Academy of Sciences of the United States of America logoLink to Proceedings of the National Academy of Sciences of the United States of America
. 1974 Mar;71(3):811–814. doi: 10.1073/pnas.71.3.811

Primitive Teratocarcinoma Cells Express a Differentiation Antigen Specified by a Gene at the T-Locus in the Mouse

Karen Artzt 1,*, Darothea Bennett 1,, François Jacob 1
PMCID: PMC388104  PMID: 4522792

Abstract

A cell-surface antigen common to mouse primitive teratocarcinoma cells, morulae, and sperm has been shown by serological methods to be specified by a wild-type T-locus gene whose mutant form is lethal in homozygotes at the morula stage.

Keywords: quantitative absorption, cytotoxicity test, embryonic antigen, morula, t12

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Artzt K., Bennett D. A genetically caused embryonal ectodermal tumor in the mouse. J Natl Cancer Inst. 1972 Jan;48(1):141–158. [PubMed] [Google Scholar]
  2. Artzt K., Dubois P., Bennett D., Condamine H., Babinet C., Jacob F. Surface antigens common to mouse cleavage embryos and primitive teratocarcinoma cells in culture. Proc Natl Acad Sci U S A. 1973 Oct;70(10):2988–2992. doi: 10.1073/pnas.70.10.2988. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. BENNETT D. ABNORMALITIES ASSOCIATED WITH A CHROMOSOME REGION IN THE MOUSE. II. EMBRYOLOGICAL EFFECTS OF LETHAL ALLELES IN THE T-REGION. Science. 1964 Apr 17;144(3616):263–267. [PubMed] [Google Scholar]
  4. BENNETT D., BADENHAUSEN S., DUNN L. C. The embryological effects of four late-lethal t-alleles in the mouse, which affect the neural tube and skeleton. J Morphol. 1959 Jul;105:105–143. doi: 10.1002/jmor.1051050105. [DOI] [PubMed] [Google Scholar]
  5. BENNETT D., DUNN L. C. REPEATED OCCURRENCES IN THE MOUSE OF LETHAL ALLELES OF THE SAME COMPLEMENTATION GROUP. Genetics. 1964 Jun;49:949–958. doi: 10.1093/genetics/49.6.949. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Bennett D., Goldberg E., Dunn L. C., Boyse E. A. Serological detection of a cell-surface antigen specified by the T (brachyury) mutant gene in the house mouse. Proc Natl Acad Sci U S A. 1972 Aug;69(8):2076–2080. doi: 10.1073/pnas.69.8.2076. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Bennett D, Dunn L C, Badenhausen S. A Second Group of Similar Lethals in Populations of Wild House Mice. Genetics. 1959 Sep;44(5):795–802. doi: 10.1093/genetics/44.5.795. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Boyse E. A., Miyazawa M., Aoki T., Old L. J. Ly-A and Ly-B: two systems of lymphocyte isoantigens in the mouse. Proc R Soc Lond B Biol Sci. 1968 Jun 11;170(1019):175–193. doi: 10.1098/rspb.1968.0032. [DOI] [PubMed] [Google Scholar]
  9. Goldberg E. H., Aoki T., Boyse E. A., Bennett D. Detection of H-2 antigens on mouse spermatozoa by the cytotoxicity test. Nature. 1970 Nov 7;228(5271):570–572. doi: 10.1038/228570a0. [DOI] [PubMed] [Google Scholar]
  10. Goldberg E. H., Boyse E. A., Bennett D., Scheid M., Carswell E. A. Serological demonstration of H-Y (male) antigen on mouse sperm. Nature. 1971 Aug 13;232(5311):478–480. doi: 10.1038/232478a0. [DOI] [PubMed] [Google Scholar]
  11. LYON M. F., MEREDITH R. INVESTIGATIONS OF THE NATURE OF T-ALLELES IN THE MOUSE. II. GENETIC ANALYSIS OF AN UNUSUAL MUTANT ALLELE AND ITS DERIVATIVES. Heredity (Edinb) 1964 May;19:313–325. doi: 10.1038/hdy.1964.34. [DOI] [PubMed] [Google Scholar]
  12. Levy J. P., Leclerc J. C., Varet B., Oppenheim E. Study of the antigenic specificity of Graffi leukemic cells. J Natl Cancer Inst. 1968 Sep;41(3):743–750. [PubMed] [Google Scholar]

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