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. 1974 Mar;71(3):815–819. doi: 10.1073/pnas.71.3.815

Alteration of Vein Cyclic 3′:5′ Nucleotide Concentrations During Changes in Contractility*

Earl W Dunham 1, Mari K Haddox 1, Nelson D Goldberg 1
PMCID: PMC388105  PMID: 4362635

Abstract

The relative changes in vascular tissue levels of cyclic 3′:5′-guanosine monophosphate (cGMP) and cyclic 3′:5′-adenosine monophosphate (cAMP) were determined in bovine and canine vein strips that were quickfrozen during changes in contractility elicited by prostaglandins (PG) or isoproterenol. Prostaglandin F2α-induced venoconstriction was associated with increased vascular tissue levels of cGMP and increased ratios of cGMP to cAMP concentrations, but no consistent qualitative change in cAMP levels. In contrast, vein cAMP concentrations were increased during administration of the vasodilators PGE2 and isoproterenol. The results suggest possible opposing roles for the two cyclic nucleotides in vasomotion.

Keywords: vascular smooth muscle, prostaglandins F2α and E2, cyclic GMP, cyclic AMP, isoproterenol

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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