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. 1974 Mar;71(3):830–834. doi: 10.1073/pnas.71.3.830

The Presence of the Lucké Herpesvirus Genome in Induced Tadpole Tumors and Its Oncogenicity: Koch-Henle Postulates Fulfilled*

Robert F Naegele 1,2, Allan Granoff 1,2, R W Darlington 1,2
PMCID: PMC388108  PMID: 4545010

Abstract

Herpesvirus extracted from a naturally occurring frog renal carcinoma (Lucké tumor) induced virus-free Lucké tumors in developing frogs. Herpesvirus recovered from an induced tumor after incubation at low temperature of tumor fragments cultured in vitro was oncogenic when injected into developing frog embryos. With the exception of the “pure culture” requirement, this experiment fulfills Koch-Henle postulates for the identification of the causative agent of the Lucké tumor.

Keywords: frog-kidney tumor, frog herpesvirus, frog embryo

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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