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. 1974 Mar;71(3):909–913. doi: 10.1073/pnas.71.3.909

Electron Spin Resonance Studies of Erythrocytes from Patients with Myotonic Muscular Dystrophy

D A Butterfield *, D B Chesnut †, A D Roses ‡,†, S H Appel ‡
PMCID: PMC388126  PMID: 4362637

Abstract

Electron magnetic resonance experiments have demonstrated that spin-labeled myotonic erythrocyte membranes have spectra that are recognizably different from those of normal erythrocytes. The spin label incorporated in the erythrocyte membranes of patients having myotonic muscular dystrophy is apparently located in a less polar and somewhat more fluid region than the label in a normal membrane. Although the mechanisms of molecular interaction and their relationship to enzymatic differences is unclear, the results lend confirmation to the suggestion that myotonic muscular dystrophy may be a disease resulting from a basic membrane abnormality.

Keywords: membrane, spin label, autosomal dominant trait

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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