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. 1974 Apr;71(4):1133–1136. doi: 10.1073/pnas.71.4.1133

The Effect of Replacement of Methionine by Homocystine on Survival of Malignant and Normal Adult Mammalian Cells in Culture

Barbara C Halpern 1,2,3, Brian R Clark 1,2,3, Dorothy N Hardy 1,2,3, Richard M Halpern 1,2,3, Roberts A Smith 1,2,3
PMCID: PMC388177  PMID: 4524624

Abstract

In tissue cultures of normal adult and malignant mammalian cells, homocystine has been substituted for methionine in a medium rich in folic acid and cyanocobalamin. Normal adult cells thrive. Three highly malignant cell types from three different species, including man, die.

Keywords: cancer, metabolic defect, vitamin B12

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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