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. 1974 Apr;71(4):1193–1196. doi: 10.1073/pnas.71.4.1193

Adriamycin and Daunorubicin Inhibition of Mutant T4 DNA Polymerases

Myron F Goodman *,†, Maurice J Bessman *, Nicholas R Bachur ‡
PMCID: PMC388190  PMID: 4524632

Abstract

The anticancer drugs, adriamycin and daunorubicin, as well as two other DNA reagents, ethidium bromide and 9-aminoacridine, all exert a differential inhibitory effect on nucleotide incorporation for purified DNA polymerases induced by mutant and wild-type bacteriophage T4. When compared with DNA polymerase of wild-type phage, antimutator enzymes are inhibited to a far greater extent and mutator enzymes to a lesser extent. In contrast, the polymerase-associated 3′-exonuclease activities of wild type and mutants are also inhibited by the compounds but nondifferentially.

Keywords: anthracycline antibiotics, DNA polymerases, mutator-antimutator genes

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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