Skip to main content
NCBI home page
Proceedings of the National Academy of Sciences of the United States of America logoLink to Proceedings of the National Academy of Sciences of the United States of America
. 1974 Apr;71(4):1215–1218. doi: 10.1073/pnas.71.4.1215

Serological Crossreactivity Between H-Y (Male) Antigens of Mouse and Man

Stephen S Wachtel 1, Gloria C Koo 1, Evelyn E Zuckerman 1, Ulrich Hammerling 1, Margrit P Scheid 1, Edward A Boyse 1
PMCID: PMC388195  PMID: 4545429

Abstract

Antisera to H-Y (male-specific) antigen were prepared by immunizing female mice with spleen cells from males of the same inbred strain. These antisera were used in mixed hemadsorption and cytotoxicity tests with cells of rats, guinea pigs, rabbits, and humans. The results showed that the H-Y components of all four species are antigenically related to H-Y of the mouse.

Keywords: histocompatibility-Y antigen, cytotoxicity tests, mammals

Full text

PDF
1215

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bennett D., Goldberg E., Dunn L. C., Boyse E. A. Serological detection of a cell-surface antigen specified by the T (brachyury) mutant gene in the house mouse. Proc Natl Acad Sci U S A. 1972 Aug;69(8):2076–2080. doi: 10.1073/pnas.69.8.2076. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Eichwald E. J., Silmser C. R. Skin. Transplant Bull. 1955;2:148–149. [PubMed] [Google Scholar]
  3. Goldberg E. H., Boyse E. A., Bennett D., Scheid M., Carswell E. A. Serological demonstration of H-Y (male) antigen on mouse sperm. Nature. 1971 Aug 13;232(5311):478–480. doi: 10.1038/232478a0. [DOI] [PubMed] [Google Scholar]
  4. Hildemann W. H., Morgan M., Frautnick L. Immunogenetic components of weaker histoincompatibility systems in mice. Transplant Proc. 1970 Mar;2(1):24–31. [PubMed] [Google Scholar]
  5. Johnson M. H., Edidin M. H-2 antigens on mouse spermatozoa. Transplantation. 1972 Dec;14(6):781–786. doi: 10.1097/00007890-197212000-00018. [DOI] [PubMed] [Google Scholar]
  6. Koo G. C., Stackpole C. W., Boyse E. A., Hämmerling U., Lardis M. P. Topographical location of H-Y antigen on mouse spermatozoa by immunoelectronmicroscopy. Proc Natl Acad Sci U S A. 1973 May;70(5):1502–1505. doi: 10.1073/pnas.70.5.1502. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Mullen Y., Hildemann W. H. X- and Y-linked transplantation antigens in rats. Transplantation. 1972 May;13(5):521–529. doi: 10.1097/00007890-197205000-00012. [DOI] [PubMed] [Google Scholar]
  8. Scheid M., Boyse E. A., Carswell E. A., Old L. J. Serologically demonstrable alloantigens of mouse epidermal cells. J Exp Med. 1972 Apr 1;135(4):938–955. doi: 10.1084/jem.135.4.938. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Silvers W. K., Yang S. L. Male specific antigen: homology in mice and rats. Science. 1973 Aug 10;181(4099):570–572. doi: 10.1126/science.181.4099.570. [DOI] [PubMed] [Google Scholar]
  10. Whittingham S., Mackay I. R. Rosette formation by human thymocytes. Cell Immunol. 1973 Mar;6(3):362–367. doi: 10.1016/0008-8749(73)90036-1. [DOI] [PubMed] [Google Scholar]

Articles from Proceedings of the National Academy of Sciences of the United States of America are provided here courtesy of National Academy of Sciences

RESOURCES