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. 1974 Apr;71(4):1474–1478. doi: 10.1073/pnas.71.4.1474

Induction of T-Cell Differentiation In Vitro by Thymin, a Purified Polypeptide Hormone of the Thymus

Ross S Basch 1,2, Gideon Goldstein 1,2
PMCID: PMC388252  PMID: 4545430

Abstract

Thymin, a purified polypeptide isolated from bovine thymus, was shown to induce the expression of differentiation antigens characteristic of thymocytes [TL and Thy-1 (θ)] when incubated in vitro with mouse bone marrow or spleen cells. This induction occurred in 5-10% of the cells from bone marrow after a 2-hr incubation with subnanogram concentrations of thymin. The induced cells expressed more TL and Thy-1 (θ) antigens than average normal thymocytes.

Keywords: thymic hormone, cytotoxic inhibition test, bone marrow cells, TL antigen, Thy-1(θ) antigen

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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