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. 1974 Apr;71(4):1530–1533. doi: 10.1073/pnas.71.4.1530

Models for Positional Information and Positional Differentiation

A Babloyantz 1, J Hiernaux 1
PMCID: PMC388264  PMID: 4524656

Abstract

It is commonly thought that the formation of patterns in developing organisms is due to the existence of a gradient of a morphogen that determines the fate of cells as a function of position in the organism. A model is presented based on a molecular mechanism where the gradient is established by the active transport of a morphogen between source and sink. The cellular differentiation and the subsequent spatial pattern formation results from the interaction of this morphogen with the genetic regulatory mechanisms of cells. Some properties of the model are given and discussed in relation to grafting experiments in hydra.

Keywords: gradient of morphogen, active transport, hydra grafting

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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