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. 1974 May;71(5):1602–1606. doi: 10.1073/pnas.71.5.1602

Blastic Transformation of Mouse Spleen Lymphocytes by a Water-Soluble Mitogen Extracted from Nocardia

Constantin Bona 1, Chantal Damais 1, Louis Chedid 1
PMCID: PMC388284  PMID: 4525452

Abstract

A water-soluble extract of Nocardia markedly increased in vitro [3H]thymidine incorporation by mouse spleen lymphocytes. The blastogenic activity of the extract and lipopolysaccharide was studied comparatively on various mouse lymphocyte subpopulations. The data obtained by [3H]thymidine incorporation and by electron microscopy have demonstrated that this preparation stimulates selectively mouse bone-marrow-derived cortisone-sensitive lymphocytes. This stimulation is related neither to a natural infection of mice with Nocardia organisms nor to the presence in Nocardia water-soluble mitogen of a lipopolysaccharide contaminant or of a lipopolysaccharide-like material.

Keywords: bone-marrow-derived lymphocytes

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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