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. 1974 May;71(5):1771–1775. doi: 10.1073/pnas.71.5.1771

Decarboxylation to Tyramine: A Major Route of Tyrosine Metabolism in Mammals

Jean-Claude David 1, Wallace Dairman 1, Sidney Udenfriend 1
PMCID: PMC388321  PMID: 4525291

Abstract

Metabolism of tyrosine was examined in mice, some of which had been treated with an inhibitor of aromatic-L-amino-acid decarboxylase. The results of the study indicate that as the plasma and tissue levels of tyrosine are elevated, decarboxylation to tyramine becomes the predominant route of metabolism. At the highest dose of tyrosine used (1.5 g/kg), it was found that 42% of the administered dose was decarboxylated within 6 hr and only 11.5% was metabolized by the tyrosine aminotransferase pathway.

Keywords: tyrosine aminotransferase pathway, decarboxylase inhibitor

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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