Abstract
Desglycinamide9-lysine vasopressin facilitates development of resistance to the analgesic action of morphine in mice if morphine is administered before the peptide. Desglycinamide9-lysine vasopressin is not a morphine antagonist, and does not appear to cause either hyperalgesia or alteration of the response to the technique used for evaluating analgesia.
Keywords: polypeptide, mice
Full text
PDF




Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Cox B. M., Osman O. H. Inhibition of the development of tolerance to morphine in rats by drugs which inhibit ribonucleic acid or protein synthesis. Br J Pharmacol. 1970 Jan;38(1):157–170. doi: 10.1111/j.1476-5381.1970.tb10344.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- EDDY N. B., LEIMBACH D. Synthetic analgesics. II. Dithienylbutenyl- and dithienylbutylamines. J Pharmacol Exp Ther. 1953 Mar;107(3):385–393. [PubMed] [Google Scholar]
- Flexner L. B., Flexner J. B., Roberts R. B. Memory in mice analyzed with antibiotics. Antibiotics are useful to study stages of memory and to indicate molecular events which sustain memory. Science. 1967 Mar 17;155(3768):1377–1383. doi: 10.1126/science.155.3768.1377. [DOI] [PubMed] [Google Scholar]
- Kayan S., Gerguson R. K., Mitchell C. L. An investigation of pharmacologic and behavioral tolerance to morphine in rats. J Pharmacol Exp Ther. 1973 May;185(2):300–306. [PubMed] [Google Scholar]
- Lande S., Flexner J. B., Flexner L. B. Effect of corticotropin and desglycinamide 9 -lysine vasopressin on suppression of memory by puromycin. Proc Natl Acad Sci U S A. 1972 Mar;69(3):558–560. doi: 10.1073/pnas.69.3.558. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Lande S., Witter A., de Wied D. Pituitary peptides. An octapeptide that stimulates conditioned avoidance acquisition in hypophysectomized rats. J Biol Chem. 1971 Apr 10;246(7):2058–2062. [PubMed] [Google Scholar]
- de Wied D., Greven H. M., Lande S., Witter A. Dissociation of the behavioural and endocrine effects of lysine vasopressin by tryptic digestion. Br J Pharmacol. 1972 May;45(1):118–122. doi: 10.1111/j.1476-5381.1972.tb09582.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
