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. 1974 May;71(5):1866–1870. doi: 10.1073/pnas.71.5.1866

Estrogen-Related Increases in Uterine Guanosine 3′:5′-Cyclic Monophosphate Levels

F A Kuehl Jr *, E A Ham *, M E Zanetti *, C H Sanford †, S E Nicol †, N D Goldberg †
PMCID: PMC388343  PMID: 4365763

Abstract

Endogenous uterine cyclic GMP and cyclic AMP concentrations were monitored at each stage of the estrus cycle; cyclic GMP concentrations were found to be highest and cyclic AMP concentrations lowest during proestrus when plasma estrogen levels have been shown to be maximal. After administration of estradiol-17β or diethylstilbestrol, the concentrations of uterine cyclic GMP in ovariectomized rats underwent a progressive and significant elevation and the levels of cyclic AMP declined significantly below control values when near maximal accumulation of tissue cyclic GMP was achieved. The increase in uterine cyclic GMP concentrations produced by estradiol benzoate administration was prevented when progesterone and the estrogen were co-administered. These results raise the possibility that an enhanced cellular accumulation of cyclic GMP may be involved in the expression of some of the actions of estrogen in uterine tissue.

Keywords: cyclic AMP, progesterone, estrus cycle

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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