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. 1974 May;71(5):1901–1905. doi: 10.1073/pnas.71.5.1901

A Neurohypophyseal Hormone Analog with Selective Oxytocin-Like Activities and Resistance to Enzymatic Inactivation: An Approach to the Design of Peptide Drugs*

Roderich Walter *, T Yamanaka †, S Sakakibara †
PMCID: PMC388350  PMID: 4525300

Abstract

Stepwise, synthetic alteration of oxytocin, guided by conformational and enzymological considerations, has led to analogs with specifically modified activity profiles and resistance to enzymatic inactivation. General requirements for the design of peptides with therapeutic value are discussed.

Keywords: conformation, hormone action, smooth muscle contractility, induction of labor

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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