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. 1974 Jun;71(6):2169–2173. doi: 10.1073/pnas.71.6.2169

Correlation Between Deoxyribonucleic Acid Excision-Repair and Life-Span in a Number of Mammalian Species

R W Hart 1,2,*, R B Setlow 1,2
PMCID: PMC388412  PMID: 4526202

Abstract

The ability of fibroblasts to perform unscheduled DNA synthesis (a measure of excision-repair) after UV irradiation was measured radioautographically for seven species at several times after several UV fluences. Both the initial rate and the maximum incorporation of [3H]dThd increased with the life-span of the species (shrew, mouse, rat, hamster, cow, elephant, man). Unscheduled DNA synthesis was approximately proportional to the logarithm of life-span.

Keywords: aging, UV irradiation, unscheduled DNA synthesis

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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