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. 1974 Jun;71(6):2236–2240. doi: 10.1073/pnas.71.6.2236

Localization of Replicating DNA of Simian Virus 40 in Monkey Kidney Cells

Donald J LeBlanc 1, Maxine F Singer 1
PMCID: PMC388426  PMID: 4366758

Abstract

Approximately 80-85% of the DNA synthesized by cells infected with simian virus 40 during a short pulse with [3H]thymidine is associated with host nuclear membrane components, as defined by the M-band technique. A substantial portion of this membrane-associated DNA has been shown to be viral specific by sedimentation studies and by DNA·DNA hybridization. Examination of DNA associated and unassociated with nuclear M-band by neutral sucrose gradient analysis suggested that while replicating DNA of simian virus 40 is attached to the nuclear membrane, mature component I DNA of simian virus 40 is released from the membrane upon completion of replication.

Keywords: nuclear membranes, M-bands

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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