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. 1974 Jun;71(6):2251–2255. doi: 10.1073/pnas.71.6.2251

The Somatic Cell Genetics of Human Interferon: Assignment of Human Interferon Loci to Chromosomes 2 and 5

Y H Tan 1, R P Creagan 1, F H Ruddle 1
PMCID: PMC388429  PMID: 4526303

Abstract

A total of 40 mouse-human cell hybrids were induced with poly(I)·poly(C) and with Newcastle disease virus. Ten hybrid clones produced low levels of human interferon in response to both the virus and poly(I)·poly(C). Concurrent enzymic and chromosomal analysis of the hybrid clones indicated a concordant segregation of these levels of human interferon with chromosomes 2 and 5. The presence of both chromosomes 2 and 5 was necessary for interferon production; neither was sufficient alone. Based on this finding, we postulate that there are at least two asyntenic gene loci for the expression of interferon in human cells.

Keywords: somatic cell hybridization, regulation

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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