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. 1974 Jun;71(6):2428–2431. doi: 10.1073/pnas.71.6.2428

Separation of Specific Initiation Factors Involved in the Translation of Myosin and Myoglobin Messenger RNAs and the Isolation of a New RNA Involved in Translation

Stuart M Heywood 1, Doris S Kennedy 1, Andre J Bester 1,*
PMCID: PMC388470  PMID: 4526305

Abstract

Two messenger specific factors, phosphocellulose fractions 3 and 4, have been isolated from the initiation factor 3 fraction of red muscle initiation factors by chromatography on phosphocellulose. When added to a reticulocyte cell-free system containing both myoglobin and myosin mRNAs, phosphocellulose fraction 3 is found to specifically stimulate the synthesis of myoglobin while phosphocellulose fraction 4 is found to specifically stimulate the synthesis of myosin. In addition, a new RNA, isolated from the initiation factor 3 fraction, is shown to specifically inhibit the translation of heterologous mRNAs.

Keywords: muscle, reticulocytes, globin synthesis, translational control

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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