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. 1974 Jun;71(6):2466–2469. doi: 10.1073/pnas.71.6.2466

Prolongation of the Life-Span in Mice Adapted to Large Amounts of L-Dopa

George C Cotzias 1, Samuel T Miller 1, Alexander R Nicholson Jr 1, William H Maston 1, Lily C Tang 1
PMCID: PMC388479  PMID: 4526220

Abstract

Various concentrations of L-dopa (levodopa, L-3,4-dihydroxyphenylalanine) were incorporated in the diets of young male Swiss albino mice, and the highest concentrations to which these mice became adapted within 3 weeks were determined. One such concentration administered indefinitely eventually induced a youthful appearance, a significantly prolonged life-span, but also corneal opacities compatible with traumatic or chemical keratitis.

Keywords: adaptation, body weight, levodopa, corneal opacities

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Selected References

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