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. 1974 Jun;71(6):2520–2524. doi: 10.1073/pnas.71.6.2520

Preferential Inhibition of the Growth of Virus-Transformed Cells in Culture by Rifazone-82, a New Rifamycin Derivative

Mina J Bissell 1, Carroll Hatie 1, Allan N Tischler 1, Melvin Calvin 1
PMCID: PMC388491  PMID: 4366963

Abstract

Rifazone-82, a new rifamycin derivative, is shown to preferentially inhibit the growth of virus-transformed chick cells in culture. Macromolecular synthesis and glucose uptake of transformed cells are also appreciably decreased in the presence of low concentrations of rifazone-82 where the normal cells appear unaffected. While rifazone-82 is shown to be a selective inhibitor of RNA-directed DNA polymerase in vitro, its action on the growth of transformed cells may involve some other mechanism.

Keywords: selective growth inhibition, virus transformation, chick fibroblasts

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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