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Proceedings of the National Academy of Sciences of the United States of America logoLink to Proceedings of the National Academy of Sciences of the United States of America
. 1974 Jul;71(7):2600–2604. doi: 10.1073/pnas.71.7.2600

Growth Control in Cultured Mouse Fibroblasts: Induction of the Pleiotypic and Mitogenic Responses by a Purified Growth Factor

P S Rudland 1,*, W Seifert 1, D Gospondarowicz 1
PMCID: PMC388513  PMID: 4527822

Abstract

Addition of serum to quiescent mouse fibroblasts induces a series of macromolecular changes (a pleiotypic response) followed by DNA synthesis and cell division. A new pituitary hormone, fibroblast growth factor, and hydrocortisone acting at physiological concentrations can completely replace exogenously added serum for the induction of these events in lines of BALB/c 3T3 cells. The induction of cell growth is specific for cultured fibroblasts; no stimulation is observed for mouse epithelial cells or virally transformed fibroblasts.

Keywords: cellular growth state, fibroblast growth factor, hydrocortisone, DNA synthesis

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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