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. 1974 Jul;71(7):2803–2807. doi: 10.1073/pnas.71.7.2803

Interaction of Phalloidin with Actin

Anneliese M Lengsfeld *, Irmentraut Löw †, Theodor Wieland †, Peter Dancker *, Wilhelm Hasselbach *
PMCID: PMC388560  PMID: 4368830

Abstract

Phalloidin, a toxic bicyclic peptide of rapid action from the toadstool, Amanita phalloides, gives rise to polymerization of G-actin to filamentous structures (Ph-actin) in a medium of low ionic strength. Ph-actin closely resembles the microfilaments found in liver membrane fractions (Ph-filaments) after in vivo or in vitro poisoning. Both phalloidin induced filaments are resistant to 0.6 M KI in contrast to F-actin, and become decorated by heavy meromyosin. After preincubation with cytochalasin B significantly fewer actin filaments are observed.

Keywords: toxin, cyclic peptide, liver cell actin, cytochalasin B, microfilaments

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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