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. 1974 Jul;71(7):2915–2918. doi: 10.1073/pnas.71.7.2915

Antipsychotic Drugs and Dopamine-Stimulated Adenylate Cyclase Prepared from Corpus Striatum of Rat Brain

M Karobath 1, H Leitich 1
PMCID: PMC388584  PMID: 4527668

Abstract

Antipsychotic drugs and their clinically impotent congeners were examined as inhibitors of dopamine-sensitive adenylate cyclase (EC 4.6.1.1) in cell-free membrane preparations of the caudate-putamen of rat brain. Of 12 neuroleptic drugs with reported antipsychotic efficacy, all inhibit stimulation of adenylate cyclase by 40 μM dopamine at micromolar concentrations. Among 14 other structurally related drugs that are not clinically effective as antipsychotic agents, 12 were almost ineffective while two drugs were moderate inhibitors of dopamine-sensitive adenylate cyclase.

Keywords: neuroleptic drugs, drug analogs

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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