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. 1974 Aug;71(8):2996–3000. doi: 10.1073/pnas.71.8.2996

The Effect of Prednisolone® upon the Metabolism and Action of 25-Hydroxy and 1,25-Dihydroxyvitamin D3

Michel Carré 1,2, Otegbeye Ayigbedé 1,2, Livia Miravet 1,2, Howard Rasmussen 1,2
PMCID: PMC388606  PMID: 4528777

Abstract

Treatment of vitamin D-deficient rats with Prednisolone® does not alter the rate of conversion of [3H]25-hydroxyvitamin D3 to [3H]1,25-dihydroxyvitamin D3, but the further conversion of [3H]1,25-dihydroxyvitamin D3 to a more polar metabolite is more rapid in the Prednisolone®-treated animals. This more polar metabolite is biologically inactive, periodate-insensitive, and persists in the intestine as long as 1,25-dihydroxyvitamin D3. Also, the time course of action of 1,25-dihydroxyvitamin D3 upon intestinal calcium transport is altered by Prednisolone® treatment. Treatment with Prednisolone® did not change the magnitude of the initial response to 1,25-dihydroxyvitamin D3 at 7 hr, but did decrease the response at 24 and 48 hr after a single dose of 1,25-dihydroxyvitamin D3. The present results show that one of the means by which large doses of adrenal corticoids alter intestinal calcium transport is by stimulating the further metabolism of 1,25-dihydroxyvitamin D3 to a more polar, biologically inactive intestinal metabolite.

Keywords: vitamin D, intestinal calcium absorption, adrenal steroids

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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