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. 1974 Aug;71(8):3009–3013. doi: 10.1073/pnas.71.8.3009

Procollagen: Intermediate Forms Containing Several Types of Peptide Chains and Non-Collagen Peptide Extensions at NH2 and COOH Ends

Marvin L Tanzer *, Robert L Church †, James A Yaeger ‡, D Eugene Wampler *, Eun-Duck Park *
PMCID: PMC388609  PMID: 4370290

Abstract

A population of procollagen molecules has been isolated from the culture medium of a clonal line of calf dermatosparactic cells and shown to have the amino-acid composition, physical properties, and molecular structure consistent with collagen precursors. Although this procollagen population shares immunologic determinants with the procollagen obtained from dermatosparactic skin, it differs from the latter in aminoacid composition, in subunit properties, and by its content of both amino and carboxyl terminal non-collagen peptide appendages. We propose that the cell culture procollagen contains earlier biosynthetic forms of dermatosparactic procollagen.

Keywords: acidic and basic polypeptides, dermatosparactic cells

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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