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. 1974 Aug;71(8):3101–3105. doi: 10.1073/pnas.71.8.3101

Kinetics of RNA Labeling in Toad Bladder Epithelium: Effects of Aldosterone and Related Steroids

B C Rossier 1,2,3, P A Wilce 1,2,3, I S Edelman 1,2,3
PMCID: PMC388629  PMID: 4213212

Abstract

Sucrose gradient analysis revealed an aldosterone-dependent increase in the incorporation of [3H]uridine into a nonmethylated, rapidly labeled RNA that sedimented at 9-12 S. This effect was antagonized by an anti-mineralocorticoid, spironolactone (SC 9420), and was not elicited either by a glucocorticoid, cortisol, or by the inactive isomer, 17-α-isoaldosterone. These findings are in accord with the inference that mRNA is induced by aldosterone during the latent period and that the induced mRNA mediates the action on sodium transport.

Keywords: mRNA synthesis, spironolactone, cortisol, sodium transport

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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