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. 1974 Aug;71(8):3167–3171. doi: 10.1073/pnas.71.8.3167

Effects of Poly(2′-O-Methyladenylic Acid) on Susceptibility and Autogenous Immunity to RNA Tumor Virus Oncogenesis In Vivo

Raymond W Tennant 1, M G Hanna Jr 1, James G Farrelly 1
PMCID: PMC388643  PMID: 4528545

Abstract

Poly(2′-O-methyladenylic acid) [poly(Am)] inhibited tumor development and death induced by the Moloney sarcoma virus-leukemia virus complex in newborn mice. The compound was effective at 10 μg per mouse when given at least 1 hr before inoculation of virus, but the greatest inhibition was seen in mice treated at least 4 hr before infection. Poly(2′-O-methyluridylic acid) and poly(vinyladenine) also inhibited sarcoma development and death but were less effective than poly(Am). Poly(Am) also enhanced the antibody response of newborn mice to endogenous leukemia virus envelope antigens, which we refer to as autogenous immunity. The results of these preliminary studies suggest that poly(Am) altered the oncogenic potential of the Moloney sarcoma-leukemia virus complex in vivo, and the effect appears to be mediated through an enhancement of the immune response of the treated animals.

Keywords: immune enhancement, Moloney sarcoma virus, Rauscher leukemia virus

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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