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. 1974 Aug;71(8):3283–3286. doi: 10.1073/pnas.71.8.3283

Continuous Lymphoid Cell Lines with Characteristics of B Cells (Bone-Marrow-Derived), Lacking the Epstein-Barr Virus Genome and Derived from Three Human Lymphomas

George Klein *, Tomas Lindahl *, Mikael Jondal *, Wolfgang Leibold *, José Menézes *, Kenneth Nilsson †, Christer Sundström †
PMCID: PMC388669  PMID: 4369887

Abstract

Three exceptional cell lines have been tested for the presence of the Epstein-Barr virus genome by nucleic acid hybridization (complementary RNA·DNA) and Epstein-Barr virus-determined nuclear antigen tests. Two lines were derived from Swedish lymphoma cases and one from an African Burkitt-like lymphoma biopsy that was negative for Epstein-Barr virus DNA and the virus-determined nuclear antigen. All three lines apparently lacked the viral genome. Two of the three lines clearly had characteristics of B-cells (bone-marrow-derived).

Keywords: membrane receptors, nucleic acid hybridization, nuclear antigen

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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