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Proceedings of the National Academy of Sciences of the United States of America logoLink to Proceedings of the National Academy of Sciences of the United States of America
. 1975 Nov;72(11):4351–4355. doi: 10.1073/pnas.72.11.4351

Thermolabile T (tumor) antigen from cells transformed by a temperature-sensitive mutant of simian virus 40.

D G Tenen, P Baygell, D M Livingston
PMCID: PMC388719  PMID: 172906

Abstract

Partially purified tumor (T) antigen from a strain of Chinese hamster lung cells transformed by wild-type simian virus 40 (SV 40) and either of two temperature-sensitive SV 40 mutants has been studied as a DNA binding protein. The DNA binding activity present in the T-antigen-containing fractions is inhibited by purified hamster anti-T IgG but not by equivalent amounts of nonimmune hamster IgG. T from either wild-type- or tsC219-transformed cells is relatively stable during heating at 44 degrees compared to T prepared from tsA239-transformed cells. These results strongly suggest that T is a product of the SV 40 A gene.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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